Vincent Mutel : rechercher sur Z-Library

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1

ChemInform Abstract: Structure—Activity Relationships of Substituted 5H-Thiazolo[3,2-a]pyrimidines as Group 2 Metabotropic Glutamate Receptor Antagonists.

Juergen Wichmann, Geo Adam, Sabine Kolczewski, Vincent Mutel, Thomas Woltering

Journal:

Année:

1999

Fichier:

PDF, 31 KB

1999

2

ChemInform Abstract: Synthesis of Heterocyclic Enol Ethers and Their Use as Group 2 Metabotropic Glutamate Receptor Antagonists.

Sabine Kolczewski, Geo Adam, Heinz Stadler, Vincent Mutel, Juergen Wichmann, Thomas Woltering

Journal:

Année:

1999

Fichier:

PDF, 29 KB

1999

3

ChemInform Abstract: Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl] -4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist.

Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Buettelmann, Ramanjit Gill, Marie-Paule Heitz, Georg Jaeschke, Vincent Mutel, Gerhard Trube, Rene Wyler

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 38 KB

english, 2001

4

4-Aminoquinolines as a Novel Class of NR1/2B Subtype Selective NMDA Receptor Antagonists.

Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Buettelmann, Marie-Paule Heitz, Vincent Mutel, Ramanjit Gill, Gerhard Trube, Rene Wyler

Journal:

Année:

2003

Fichier:

PDF, 76 KB

2003

5

2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a Novel Class of NR1/2B Subtype Selective NMDA Receptor Antagonists.

Bernd Buettelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, Rene Wyler

Journal:

Année:

2003

Fichier:

PDF, 100 KB

2003

6

4-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinolines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists.

Bernd Buettelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, Rene Wyler

Journal:

Année:

2003

Fichier:

PDF, 77 KB

2003

7

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a Novel Class of NR1/2B Subtype Selective NMDA Receptor Antagonists.

Alexander Alanine, Anne Bourson, Bernd Buettelmann, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, Rene Wyler

Journal:

Année:

2004

Fichier:

PDF, 94 KB

2004

8

9H-Xanthene-9-carboxylic Acid [1,2,4]Oxadiazol-3-yl- and (2H-Tetrazol-5-yl)-amides as Potent, Orally Available mGlu1 Receptor Enhancers.

Eric Vieira, Joerg Huwyler, Synese Jolidon, Frederic Knoflach, Vincent Mutel, Juergen Wichmann

Journal:

Année:

2006

Fichier:

PDF, 13 KB

2006

9

Asymmetric Synthesis and Receptor Pharmacology of the Group II mGlu Receptor Ligand (1S,2R,3R,5R,6S)-2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid—HYDIA

Thomas J. Woltering, Geo Adam, Philipp Huguenin, Jürgen Wichmann, Sabine Kolczewski, Silvia Gatti, Anne Bourson, James N. C. Kew, Grayson Richards, John A. Kemp, Vincent Mutel, Frédéric Knoflach

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 584 KB

english, 2008

10

Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: Correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPγs binding

Grayson Richards, Jürg Messer, Pari Malherbe, Richard Pink, Manfred Brockhaus, Heinz Stadler, Jürgen Wichmann, Hervé Schaffhauser, Vincent Mutel

Journal:

The Journal of Comparative Neurology

Année:

2005

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2005

11

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

Thomas J. Woltering, Jürgen Wichmann, Erwin Goetschi, Geo Adam, James N.C. Kew, Frédéric Knoflach, Theresa M. Ballard, Jörg Huwyler, Vincent Mutel, Silvia Gatti

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 167 KB

english, 2008

12

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

Eric Vieira, Jörg Huwyler, Synèse Jolidon, Frédéric Knoflach, Vincent Mutel, Jürgen Wichmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 183 KB

english, 2005

13

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1

Thomas J. Woltering, Geo Adam, Alexander Alanine, Jürgen Wichmann, Frédéric Knoflach, Vincent Mutel, Silvia Gatti

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 150 KB

english, 2007

14

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

Thomas J. Woltering, Geo Adam, Jürgen Wichmann, Erwin Goetschi, James N.C. Kew, Frédéric Knoflach, Vincent Mutel, Silvia Gatti

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 307 KB

english, 2008

15

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

Eric Vieira, Jörg Huwyler, Synèse Jolidon, Frédéric Knoflach, Vincent Mutel, Jürgen Wichmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 273 KB

english, 2009

16

Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Büttelmann, Ramanjit Gill, Marie-Paule Heitz, Georg Jaeschke, Vincent Mutel, Gerhard Trube, René Wyler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 158 KB

english, 2001

17

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Büttelmann, Marie-Paule Heitz, Vincent Mutel, a Ramanjit Gill, Gerhard Trube, René Wyler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 145 KB

english, 2002

18

4-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

Bernd Büttelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, René Wyler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 169 KB

english, 2003

19

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

Alexander Alanine, Anne Bourson, Bernd Büttelmann, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, René Wyler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 218 KB

english, 2003

20

Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

Jürgen Wichmann, Geo Adam, Sabine Kolczewski, Vincent Mutel, Thomas Woltering

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 180 KB

english, 1999

21

Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists

Sabine Kolczewski, Geo Adam, Heinz Stadler, Vincent Mutel, Jürgen Wichmann, Thomas Woltering

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 162 KB

english, 1999

22

In Vitro Binding Properties in Rat Brain of [3H]Ro 25-6981, a Potent and Selective Antagonist of NMDA Receptors Containing NR2B Subunits

Vincent Mutel, Danièle Buchy, Agnès Klingelschmidt, Jürg Messer, Zaiga Bleuel, John A. Kemp, John Grayson Richards

Journal:

Journal of Neurochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1998

23

Binding Characteristics of a Potent AMPA Receptor Antagonist [3H]Ro 48-8587 in Rat Brain

Vincent Mutel, Gerhard Trube, Agnès Klingelschmidt, Jürg Messer, Zaiga Bleuel, Urs Humbel, Merwyn M. Clifford, Gareth J. Ellis, J. Grayson Richards

Journal:

Journal of Neurochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 1.14 MB

english, 1998

24

Characterization of (2S,2′R,3′R)-2-(2′,3′-[3H]-Dicarboxycyclopropyl)glycine Binding in Rat Brain

Vincent Mutel, Geo Adam, Sylvie Chaboz, John A. Kemp, Agnés Klingelschmidt, Jürg Messer, Jürgen Wichmann, Thomas Woltering, John Grayson Richards

Journal:

Journal of Neurochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 835 KB

english, 1998

25

Characterization of [3H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections

Vincent Mutel, Gareth J. Ellis, Geo Adam, Sylvie Chaboz, Agnes Nilly, Jürg Messer, Zaiga Bleuel, Veit Metzler, Pari Malherbe, Ernst-Jürgen Schlaeger, Brian S. Roughley, Richard L. M. Faull, J. Grayson

Journal:

Journal of Neurochemistry

Année:

2000

Langue:

english

Fichier:

PDF, 606 KB

english, 2000

26

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists

Georg Jaeschke, Richard Porter, Bernd Büttelmann, Simona M. Ceccarelli, Wolfgang Guba, Bernd Kuhn, Sabine Kolczewski, Jörg Huwyler, Vincent Mutel, Jens-Uwe Peters, Theresa Ballard, Eric Prinssen, Eric

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 206 KB

english, 2007

27

2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Bernd Büttelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, René Wyler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 163 KB

english, 2003

28

Opposite effects of Zn on the in vitro binding of [3H]LY354740 to recombinant and native metabotropic glutamate 2 and 3 receptors

Pari Malherbe, J. Grayson Richards, Clemens Broger, Marie-Thérèse Zenner, Jürg Messer, Claudia Kratzeisen, Shigetada Nakanishi, Vincent Mutel

Journal:

Journal of Neurochemistry

Année:

2005

Langue:

english

Fichier:

PDF, 429 KB

english, 2005

29

mGluR-evoked augmentation of receptor-mediated cyclic AMP formation in neonatal and adult rat striatum

Jayne Cartmell, Hervé Schaffhauser, Jürgen Wichmann, Vincent Mutel

Journal:

British Journal of Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 354 KB

english, 1997

30

Characterization of [3H]-(2S,2′R,3′R)-2-(2′,3′-dicarboxy- cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes

Jayne Cartmell, Geo Adam, Sylvie Chaboz, Robert Henningsen, John A. Kemp, Agnes Klingelschmidt, Veit Metzler, Frederick Monsma, Hervé Schaffhauser, Jürgen Wichmann, Vincent Mutel

Journal:

British Journal of Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 331 KB

english, 1998

31

Effect of the umami peptides on the ligand binding and function of rat mGlu4a receptor might implicate this receptor in the monosodium glutamate taste transduction

Katherine Monastyrskaia, Kenneth Lundstrom, Doris Plahl, Gonzalo Acuna, Christophe Schweitzer, Pari Malherbe, Vincent Mutel

Journal:

British Journal of Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 220 KB

english, 1999

32

Control of Bioamine Metabolism by 5-HT2B and α1D Autoreceptors through Reactive Oxygen Species and Tumor Necrosis Factor-α Signaling in Neuronal Cells

BENOIT SCHNEIDER, MATHÉA PIETRI, SOPHIE MOUILLET-RICHARD, MYRIAM ERMONVAL, VINCENT MUTEL, JEAN-MARIE LAUNAY, ODILE KELLERMANN

Journal:

Annals of the New York Academy of Sciences

Année:

2006

Langue:

english

Fichier:

PDF, 247 KB

english, 2006

33

Cellular Prion Protein Signaling in Serotonergic Neuronal Cells

SOPHIE MOUILLET-RICHARD, BENOÎT SCHNEIDER, ELODIE PRADINES, MATHÉA PIETRI, MYRIAM ERMONVAL, JACQUES GRASSI, J. GRAYSON RICHARDS, VINCENT MUTEL, JEAN-MARIE LAUNAY, ODILE KELLERMANN

Journal:

Annals of the New York Academy of Sciences

Année:

2007

Langue:

english

Fichier:

PDF, 220 KB

english, 2007

34

Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice

Grayson Richards, Jürg Messer, Richard L.M. Faull, Heinz Stadler, Jürgen Wichmann, Philipp Huguenin, Bernd Bohrmann, Vincent Mutel

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 2.03 MB

english, 2010

35

Multiple pathways for regulation of the KCl-induced [3H]-GABA release by metabotropic glutamate receptors, in primary rat cortical cultures

Hervé Schaffhauser, Frédéric Knoflach, John Richard Pink, Zaiga Bleuel, Jayne Cartmell, Fabienne Goepfert, John A Kemp, John Grayson Richards, Geo Adam, Vincent Mutel

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 859 KB

english, 1998

36

Effect of metabotropic glutamate receptor activation on receptor-mediated cyclic AMP responses in primary cultures of rat striatal neurones

Jayne Cartmell, Fabienne Goepfert, Frédéric Knoflach, J.Richard Pink, Zaiga Bleuel, J.Grayson Richards, Hervé Schaffhauser, John A. Kemp, Jürgen Wichmann, Vincent Mutel

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 1001 KB

english, 1998

37

Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit

David R Lynch, Sandra S Shim, Kristen M Seifert, Sushmithi Kurapathi, Vincent Mutel, Michael J Gallagher, Rodney P Guttmann

Journal:

European Journal of Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 238 KB

english, 2001

38

Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors

Jürgen Wichmann, Konrad Bleicher, Eric Vieira, Thomas Woltering, Frédéric Knoflach, Vincent Mutel

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 89 KB

english, 2002

39

Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist: Effects on apparent agonist affinities

Andrew J. Sleight, Nico J. Stam, Vincent Mutel, Patrick M.L. Vanderheyden

Journal:

Biochemical Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 699 KB

english, 1996

40

Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs

François Jenck, Jean-Luc Moreau, Vincent Mutel, James R. Martin, Willy E. Haefely

Journal:

European Journal of Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 656 KB

english, 1993

41

Reversal of L-CCG-I-Mediated long term depression in the dentate gyrus by subsequent application of MCPG

Vincent Mutel, Jean-Maxime Ducarre, John A. Kemp

Journal:

Neuropharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 132 KB

english, 1996

42

A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor

James A. Dias, Béatrice Bonnet, Barbara A. Weaver, Julie Watts, Kerri Kluetzman, Richard M. Thomas, Sonia Poli, Vincent Mutel, Brice Campo

Journal:

Molecular and Cellular Endocrinology

Année:

2011

Langue:

english

Fichier:

PDF, 336 KB

english, 2011

43

Pharmacological properties of native metabotropic glutamate receptors in freshly dissociated Golgi cells of the rat cerebellum

Frédéric Knoflach, Thomas Woltering, Geo Adam, Vincent Mutel, John A Kemp

Journal:

Neuropharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 132 KB

english, 2001

44

Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice

James N.C. Kew, Marie-Claire Pflimlin, John A. Kemp, Vincent Mutel

Journal:

Neuropharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 114 KB

english, 2002

45

Characterization of [3H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors

Christophe Schweitzer, Claudia Kratzeisen, Geo Adam, Kenneth Lundstrom, Pari Malherbe, Serge Ohresser, Heinz Stadler, Jürgen Wichmann, Thomas Woltering, Vincent Mutel

Journal:

Neuropharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 116 KB

english, 2000

46

Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum

Pari Malherbe, James N.C. Kew, J.Grayson Richards, Frédéric Knoflach, Claudia Kratzeisen, Marie-Thérèse Zenner, Richard L.M. Faull, John A. Kemp, Vincent Mutel

Journal:

Molecular Brain Research

Année:

2002

Langue:

english

Fichier:

PDF, 800 KB

english, 2002

47

Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8

Pari Malherbe, Claudia Kratzeisen, Kenneth Lundstrom, J.Grayson Richards, Richard L.M Faull, Vincent Mutel

Journal:

Molecular Brain Research

Année:

1999

Langue:

english

Fichier:

PDF, 1.62 MB

english, 1999

48

l-AP4 inhibition of depolarization-evoked cGMP formation in rat cerebellum

Jayne Cartmell, John A Kemp, Vincent Mutel

Journal:

Neuroscience Letters

Année:

1997

Langue:

english

Fichier:

PDF, 115 KB

english, 1997

49

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

Guy A. Higgins, Theresa M. Ballard, James N.C. Kew, J. Grayson Richards, John A. Kemp, Geo Adam, Thomas Woltering, Shigetada Nakanishi, Vincent Mutel

Journal:

Neuropharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 481 KB

english, 2004

50

Involvement of a cyclic-AMP pathway in group I metabotropic glutamate receptor responses in neonatal rat cortex

Hervé Schaffhauser, Jean de Barry, Hélène Muller, Marie-Paule Heitz, Georges Gombos, Vincent Mutel

Journal:

European Journal of Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 778 KB

english, 1997